Smartox Biotechnology
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Smartox Biotechnology
离子通道研究用多肽毒素的专业化生产商
Smartox Biotechnology是全球**一家专门生产动物毒液多肽毒素，用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。
Smartox Biotechnology于2009年由来自Grenoble神经科学研究所(Grenoble Institute of Neuroscience)的Michel de waard博士创立,Smartox Biotechnology专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为毒素）。De Waard博士研究离子通道与毒素多肽的关系，尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽(cell penetrating peptides, CPP)。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。2010年，Smartox Biotechnolgy被法国研究部(Ministry of Research)授予“新兴企业OSEO奖(OSEO prize for emerging businesses)”。
总之，Smartox Biotechnology提供一系列高质量、具开创价值的多肽毒素。这些化合物在离子通道 研究中具有高的亲和性和选择性，是相应领域科学研究理想的生物毒素提供商和贴心的合作伙伴。
Smartox Biotechnology的毒素产品包括：
钠离子通道(Sodium channel)
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Toxin name
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Catalog #
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Target
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Phrixotoxin-3
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13PHX003
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Selective blocker of Nav1.2
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µ-conotoxin GIIIB
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CON020
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Selective blocker of Nav1.4
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µ-conotoxin CnIIIC
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CON021
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Selective blocker of Nav1.4
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μ-conotoxin PIIIA
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08CON006
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Selective blocker of Nav1.4
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Jingzhaotoxin-III
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12JZH003
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Selective blocker of Nav1.5
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ProTx-II
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07PTX002
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Selective blocker of Nav1.7
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ProTx-II Biotin
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12PTB002
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Selective blocker of Nav1.7
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ProTx-I
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12PTX001
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Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7
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Huwentoxin-I
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07HWT001
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Blocker of TTX-S
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Huwentoxin-IV
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08HWT002
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Blocker of TTX-S
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Hainantoxin-III
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13HTX003
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Blocker of TTX-S
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Hainantoxin-IV
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12HTX001
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Blocker of TTX-S
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GsAF-I
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12GSF001
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Blocker of TTX-S
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GsAF-II
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12GSF002
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Blocker of TTX-S
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钾离子通道(Potassium channel)
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KCa channels
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Toxin name
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Catalog #
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Target
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Description
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Apamin
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08APA001
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SK1, SK2, SK3
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Charybdotoxin
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11CHA001
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KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6
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Iberiotoxin
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12IBX001
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KCa1.1
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Leiurotoxin 1 (Scyllatoxin)
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10LEI001
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SK1, SK2, SK3
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Tamapin
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10TAM001
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SK1, SK2, SK3
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Kaliotoxin-1
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08KTX002
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BK, Kv1.1, Kv1.2, Kv1.3
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Kv channels
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ShK
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08SHK001
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Kv1.3, Kv1.1, Kv1.4, Kv1.6
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TMR-ShK
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SAT001
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Kv1.3, Kv1.1
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Margatoxin
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08MAG001
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Kv1.3
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(Dap22)-ShK
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13SHD001
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Kv1.3
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ADWX-1
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13ADW001
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Kv1.3
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HsTx1
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08NEU001
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Kv1.3, Kv1.2
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Agitoxin-2
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13AGI002
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Kv1.3, Kv1.1
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Maurotoxin
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08MAR001
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Kv1.2, KCa3.1
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Guangxitoxin 1E
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11GUA002
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Kv2.1, Kv2.2
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Stromatoxin 1 NEW
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SCT01
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Kv2.1, Kv2.2
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Kaliotoxin-1
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08KTX002
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BK, Kv1.1, Kv1.2, Kv1.3
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Charybdotoxin
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11CHA001
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KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6
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Phrixotoxin-2
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PHX002
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Kv4.2, Kv4.3
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AmmTx3 NEW
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AMX001
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A-type potassium channels
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Inwardly rectifying potassium channels
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TertiapinQ
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08TER001
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Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1
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hERG/Kv11.1
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BeKm-1
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13BEK001
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ERG1
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钙离子通道(Calcium channel)
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High voltage-gated Ca2+ channels
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Toxin name
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Catalog#
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Target
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Description
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ω-agatoxin IVA
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11AGA001
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P/Qtype
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ω-Conotoxin MVIIC
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08CON002
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P/Qtype, N-type
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ω-Conotoxin MVIIA
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08CON001
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N-type
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ω-Conotoxin GVIA
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08CON003
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N-type
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ω-Conotoxin SO3
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08CON013
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N-type
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Huwentoxin I
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07HWT001
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N-type
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ProTx-II
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07PTX002
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T-type, L-type
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Intermediate voltage-gated Ca2+ channels
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SNX482
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08SNX002
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R-type
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Low voltage-gated Ca2+ channels
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ProTx-I
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12PTX001
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T-type
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ProTx-II
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07PTX002
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T-type, L-type
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Ryanodine receptors
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Maurocalcine
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07PAU001
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Ryr1
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氯离子通道(Chloride channel)
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Toxin name
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Catalog #
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Target
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Description
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Chlorotoxin
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08CHL001
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Blocker of small conductance Cl- channels
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GaTx1
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13GTX001
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Selective blocker of CFTR channel
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GaTx2
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10GTX002
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Selective blocker of ClC-2 channel
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乙酰胆碱受体(Acetylcholine receptor)
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Toxin name
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Catalog #
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Target
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Description
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α-conotoxin PeIA
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13CON017
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α9α10, α3β2 subunits
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αC-Conotoxin PrXA
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13CON016
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α1/β1/ε/δ, α1/β1/γ/δ subunits
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Waglerin-1
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12WAG001
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MusclenAChR
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α-conotoxin MI
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08CON012
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α1/δsubunits
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α-conotoxin GI
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08CON005
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α/δsite
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α-conotoxin IMI
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08CON011
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α7 homomeric nAChR
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α-conotoxin GID
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CON019
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Blocker of α3β2, α7 and α4β2 nAChRs
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含N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)
Conantokin-G选择性、特异性抑制含NR2B的NMDAR。Conantokin-G能剂量依赖性抑制Ca2+内流，抑制NMDA诱导的兴奋性中毒效应。研究表明，在小鼠皮层神经元，Conantokin-G阻滞NMDA引发的电流信号的IC50值为480 nM。
酸敏感离子通道(ASIC channel, Acid-Sensing Ion Channel)
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Toxin name
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Catalog #
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Target
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Description
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APETx2
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07APE002
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Selective blocker of ASIC3
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Psalmotoxin1/PcTx1
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13PCT001
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Selective blocker of ASIC1a
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Ugr9-1
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13UGR001
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Blocker of ASIC3
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瞬时受体电位(TRP channel, transient receptor potential)
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Toxin name
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Catalog #
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Target
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Description
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GsMTx4
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08GSM001
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TRPC, TRPA
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Vanillotoxin3
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10VAN003
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Activator of TRPV1
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ProTx-I
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12PTX001
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Antagonist of TRPA1
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嘌呤能通道(Purinergic channel)
Purotoxin-1
选择性抑制P2X3受体。100 nM Purotoxin-1 (PT-1)选择性抑制P2X3受体通道，在大鼠DRG神经元上，使用膜片钳实验表明：PT-1对电压门控通道和TRPV1均无抑制效应。10 µM ATP和100 µM α,β Methylene-ATP浓度下Purotoxin-1对P2X3受体有选择性作用，在该ATP浓度下Purotoxin-1对P2X2和杂化二聚体P2X2/3并无激动作用。
Purotoxin-1对疼痛的潜在治疗作用。
其它膜受体通道(Others)
Smartox Biotechnology还提供其他类型的膜受体抑制剂：
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Toxin name
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Catalog#
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Target
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Morphiceptin
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011CAS001
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Agonist of µ-opoid receptors
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Lys-conopressin G
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11CON14
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Vasopressin-like peptide
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GsMTx4
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08GSM001
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Mechano sensitive ion channels
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Obtustatin
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10OBT001
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Blocks the binding of α1β1 integrin to collagen IV
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Rho-Conotoxin TIA
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CON022
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Blocks α1-adrenergic receptor
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