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    DiscoverX JAK1, active 14-918-K
    品牌：Eurofins DiscoverX
    货号：14-918-K
    规格：14-918-K
    货期：DiscoverX

    品牌：DiscoverX 品名：JAK1, active 货号：14-918-K 规格：Bulk

    商品详情 参考文献 相关资料

    品牌：DiscoverX
    品名：JAK1, active 
    货号：14-918-K 
    规格：Bulk


    简要说明：

    JAK1, active

    N-terminal GST-tagged recombinant, human JAK1 amino acids 866-end. Activated in vitro by auto-phosphorylation. Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-α/beta and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.


    产品介绍：

    Target
    JAK1
    Expression System
    Expressed by baculovirus in Sf21 insect cells
    Application
    Kinase Assay
    Molecular Weight
    61 kDa
    Accession Number
    NM_002227
    Species
    Human
    Tag
    GST
    Purification Method
    Glutathione Sepharose™ affinity chromatography
    Content
    Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 5mM β-glycerophosphate, 0.5mM sodium orthovanadate, 50% v/v glycerol, 0.02% Triton® X-100, 0.5mM EDTA, 2mM DTT. Frozen solution.
    Storage
    6 months at -70°C
    Bulk Sizes
    Inquire

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