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    上海橙子视频app安卓下载生物科技公司
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    DiscoverX BTK (E41K), active 14-773-K
    品牌：Eurofins DiscoverX
    货号：14-773-K
    规格：14-773-K
    货期：Eurofins DiscoverX
    应用： 点击这里给我发消息  咨询客服

    品牌：DiscoverX 品名：BTK (E41K), active 货号：14-773-K 规格：Bulk

    商品详情 参考文献 相关资料

    品牌：DiscoverX
    品名：BTK (E41K), active
    货号：14-773-K
    规格：Bulk 

    简要说明：

    BTK (E41K), active

    N-terminal 6His-tagged recombinant, human full length BTK. Specific mutations within the pleckstrin homology (PH) domain of BTK results in human X-linked aγglobulinemia (XLA). The E41K substitution, identified through random mutagenesis, is a PH domain gain-of-function mutation that has been shown to be associated with increased membrane localization and tyrosine phosphorylation of BTK. Using animal models, this mutation has been shown to arrest the development of immature B cells and to act as a tumour suppressor in B-cell linker protein (BLNK/SLP-65)-deficient hosts. (Li, .et al., Immunity,(1995);2:451-460 and Baraldi, E., et al., Structure,(1999);7:449-460).

    产品介绍：

    Target
    BTK
    Expression System
    Expressed by baculovirus in Sf21 insect cells
    Application
    Kinase Assay
    Molecular Weight
    78.4 kDa
    Accession Number
    NM_000061
    Species
    Human
    Tag
    6His
    Purification Method
    Ni2+/NTA-agarose
    Storage
    6 months at -70°C
    Bulk Sizes
    Inquire



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