Catalogue number
ANT-211
Synonyms
MYC, CMYC, C-MYS, V-MYC, P64.
Type
Mouse Anti Human Monoclonal.
Introduction
c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocations of c-Myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Clone
NYRhc-myc.
Immunogen
synthetic peptides.
Ig Subclass
mouse IgG1.
Purification Method
Protein A.
Formulation
1mg/ml in PBS (after reconstitution).
Storage Procedures
Antibody is shipped lyophilized at ambient temperature.
Solubility
Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Titer
By Western blot 1:2,000 dilution will yield a strong band in WB.
Safety Data Sheet
Note
This antibody was produced in BALB/c mice.
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
