Catalogue number
PRO-1883
Synonyms
Keratin 17, PCHC1, 39.1, CK-17, K17, PC2, PC, cytokeratin-17,
Keratin 17 Epitope S1, Keratin 17 Epitope S2, Keratin 17 Epitope S4, Keratin,
Type I Cytoskeletal 1, keratin-17, Cytokeratin-17, Keratin-17.
Introduction
Cytokeratin
17 also known as KRT17 is a type I cytokeratin. KRT17 is found in nail beds,
hair follicles, sebaceous glands, and other epidermal appendages. Mutations in
KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma
multiplex. KRT17 takes part in the formation and maintenance of a variety of
skin appendages, particularly in determining shape and orientation of hair. KRT17
also modulates the function of TNF-alpha in the precise context of hair
cycling. Moreover, KRT17 regulates protein synthesis and epithelial cell growth
all through binding to the adapter protein SFN and by stimulating Akt/mTOR
pathway.
Description
KRT17 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 455 amino acids (1-432 a.a) and
having a molecular mass of 50.5kDa.
KRT17 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
KRT17 protein solution (0.5mg/ml) containing 20mM Tris-HCl
buffer (pH8.0), 10% glycerol and 0.4M Urea.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 90% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMTTSIRQ FTSSSSIKGS SGLGGGSSRT SCRLSGGLGA GSCRLGSAGG
LGSTLGGSSY SSCYSFGSGG GYGSSFGGVD GLLAGGEKAT MQNLNDRLAS YLDKVRALEE ANTELEVKIR
DWYQRQAPGP ARDYSQYYRT IEELQNKILT ATVDNANILL QIDNARLAAD DFRTKFETEQ ALRLSVEADI
NGLRRVLDEL TLARADLEMQ IENLKEELAY LKKNHEEEMN ALRGQVGGEI NVEMDAAPGV DLSRILNEMR
DQYEKMAEKN RKDAEDWFFS KTEELNREVA TNSELVQSGK SEISELRRTM QALEIELQSQ LSMKASLEGN
LAETENRYCV QLSQIQGLIG SVEEQLAQLR CEMEQQNQEY KILLDVKTRL EQEIATYRRL LEGEDAHLTQ
YKKEPVTTRQ VRTIVEEVQD GKVISSREQV HQTTR
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
