Catalogue number
PRO-2156
Synonyms
SCO1 Cytochrome C Oxidase Assembly Protein, SCOD1, SCO
(Cytochrome Oxidase Deficient, Yeast) Homolog 1, SCO Cytochrome Oxidase
Deficient Homolog 1 (Yeast), SCO Cytochrome Oxidase Deficient Homolog 1, Protein
SCO1 Homolog, Mitochondrial, SCOD1, Protein SCO1 homolog, mitochondrial.
Introduction
SCO Cytochrome Oxidase Deficient Homolog 1, also known as SCO1 is a
member of the SCO1/2 family. Mammalian cytochrome c oxidase (COX) catalyzes the
transfer of reducing equivalents from cytochrome c to molecular oxygen and
pumps protons across the inner mitochondrial membrane. Furthermore, in yeast, two
related COX assembly genes, SCO1 & SCO2 which are synthesis of cytochrome c
oxidase, enable subunits 1 as well as 2 to be incorporated into the
holoprotein. This gene is the human homolog to the yeast SCO1 gene. Among the diseases
associated with SCO1 are hepatic failure, early-onset, neurologic disorder due
to cytochrome c oxidase deficiency and fatal infantile cytochrome c oxidase
deficiency.
Description
SCO1 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 179 amino acids (132-301 a.a) and
having a molecular mass of 20.5kDa.
SCO1 is fused to a 9 amino acid His-tag at C-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile filtered colorless solution.
Formulation
SCO1 protein solution (1mg/ml) containing Phosphate
buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 95% as determined by SDS-PAGE.
Amino acid sequence
MGKPLLGGPF SLTTHTGERK TDKDYLGQWL LIYFGFTHCP DVCPEELEKM
IQVVDEIDSI TTLPDLTPLF ISIDPERDTK EAIANYVKEF SPKLVGLTGT REEVDQVARA YRVYYSPGPK
DEDEDYIVDH TIIMYLIGPD GEFLDYFGQN KRKGEIAASI ATHMRPYRKK SLEHHHHHH.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
