Catalogue number
PRO-1759
Synonyms
Snail Family Zinc Finger 1, Protein
Sna, Protein Snail Homolog 1, SNAH, Snail 1 (Drosophila Homolog), Zinc Finger
Protein, Snail Homolog 1 (Drosophila), SLUGH2, SNA, SNAIL, SNAIL1, dJ710H13.1, Snail
1 Homolog, Snail 1 Zinc Finger Protein, Snail 1, Zinc Finger Protein, Snail
Homolog 1, Zinc Finger Protein SNAI1.
Introduction
Snail
homolog 1 (SNAI1) is involved in induction of the epithelial to mesenchymal
transition (EMT), formation and maintenance of embryonic mesoderm, growth
arrest, survival and cell migration. SNAI1 binds to 3 E-boxes of the E-cadherin
gene promoter
and represses its transcription. The nuclear protein encoded by SNAI1 is
structurally identical to the Drosophila snail protein, and is considered as
well to be vital for mesoderm formation in the developing embryo. At least two
variants of a similar processed pseudogene have been found on chromosome 2. Among the diseases associated with SNAI1 are waardenburg
syndrome type iid, and inappropriate adh syndrome.
Description
SNAI1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-264 a.a) and having a molecular mass of 31.5kDa.
SNAI1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
SNAI1 protein solution (1mg/ml) containing 20mM Tris-HCl
buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 85% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMPRSFLV RKPSDPNRKP NYSELQDSNP EFTFQQPYDQ AHLLAAIPPP
EILNPTASLP MLIWDSVLAP QAQPIAWASL RLQESPRVAE LTSLSDEDSG KGSQPPSPPS PAPSSFSSTS
VSSLEAEAYA AFPGLGQVPK QLAQLSEAKD LQARKAFNCK YCNKEYLSLG ALKMHIRSHT LPCVCGTCGK AFSRPWLLQG HVRTHTGEKP
FSCPHCSRAF ADRSNLRAHL QTHSDVKKYQ CQACARTFSR MSLLHKHQES GCSGCPR
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
