Catalogue number
CYT-889
Synonyms
Tumor Necrosis Factor Receptor Superfamily, Member 10c,
Decoy Without An , Intracellular Domain, TRAILR3, DCR1, TRID, TNF-Related
Apoptosis-Inducing Ligand Receptor, Antagonist Decoy Receptor For TRAIL/Apo-2L,
Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, Decoy
Receptor,TRAIL-R, LIT,Tumor Necrosis Factor Receptor Superfamily Member 10C, TRAIL
Receptor Without an Intracellular Domain, Cytotoxic TRAIL Receptor, TRAIL
Receptor, CD263 Antigen, DCR1-TNFR, CD263.
Introduction
TRAIL Receptor-3, also known as TNFRSF10C belongs to the TNF-receptor
super family. TNFRSF10C contains an extracellular TRAIL-binding domain as well
as a transmembrane domain, however no cytoplasmic
death domain. Furthermore, TNFRSF10C is not capable of inducing apoptosis, and
is considered to act as an antagonistic receptor
which protects cells from TRAIL-induced apoptosis.
Description
TNFRSF10C Human Recombinant produced in E. coli is a
single, non-glycosylated polypeptide chain containing 234 amino acids (26-236 a.a)
and having a molecular mass of 24.6 kDa.
TNFRSF10C is fused to a 23 amino acid His-tag at
N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
TNFRSF10C protein solution (1mg/ml) containing Phosphate
buffered saline (pH7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH
SSGLVPRGSH MGSATTARQE
EVPQQTVAPQ QQRHSFKGEE CPAGSHRSEH TGACNPCTEG VDYTNASNNE PSCFPCTVCK SDQKHKSSCT
MTRDTVCQCK EGTFRNENSP EMCRKCSRCP SGEVQVSNCT SWDDIQCVEE FGANATVETP AAEETMNTSP
GTPAPAAEET MNTSPGTPAP AAEETMTTSP GTPAPAAEET MTTSPGTPAP AAEETMTTSP GTPA.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
