Catalogue number
PRO-556
Synonyms
Complement C4c, Complement Component C4c, C4c.
Introduction
Complement C4c is a degradation product of C4b which is cleaved by C4b/C3b inactivator to yield C4d and C4c.
Complement C4c interacts with C1 and C2 to form C3 convertase of the classic activation pathway. Systemic lupus erythematosus (SLE) is often associated with congenital C4 deficiency. Reduced levels of components of the classic pathway (C1, C2, C4, C3) are common after such activation, e.g. in SLE, acute serum sickness and conditions associated with circulating immune complexes.
Description
Human C4c produced in Human plasma having a molecular mass of 210 kDa.
Source
Human Plasma.
Physical Appearance
Sterile Filtered clear solution.
Formulation
The Human Complement C4c solution is in Sodium Phosphate buffer pH 7.0 containing 0.15M NaCl and 0.09% NaN3.
Stability
Human C4c although stable at 4°C for 1 week, should be stored at -15°C.
Please avoid freeze-thaw cycles.
Purity
Greater than 99.0%.
Human Virus Test
Plasma from each donor has been tested and found negative for HIV-1 & 2 antibodies, Hepatatis B surface antigen, and Hepatatis C antibodies.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
