Catalogue number
PRO-2092
Synonyms
Ectodysplasin A Receptor, DL, Ectodysplasin 1, Anhidrotic
Receptor, Anhidrotic Ectodysplasin Receptor 1, Ectodermal Dysplasia Receptor,
Ectodysplasin-A Receptor, Downless Homolog, EDA-A1 Receptor, ECTD10A, ECTD10B, EDA3,
HRM1, ED3, Tumor Necrosis Factor Receptor Superfamily Member EDAR, Downless,
Mouse, Homolog Of, EDA-A1R, EDA1R, ED1R, ED5, Tumor necrosis factor receptor
superfamily member EDAR.
Introduction
Ectodysplasin A Receptor, also known as EDAR belongs to the tumor
necrosis factor receptor family. EDAR is
a receptor for the soluble ligand ectodysplasin A, and is capable of activating
the nuclear factor-kappaB, JNK, as well as caspase-independent cell death
pathways. EDAR is necessary for the development of hair, teeth, and other
ectodermal derivatives. Furthermore, mutations in EDAR resulted in autosomal
dominant and recessive forms of hypohidrotic ectodermal dysplasia.
Description
EDAR Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 445 amino acids (27-448 a.a) and
having a molecular mass of 48.2kDa.
EDAR is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
EDAR protein solution (0.25mg/ml) containing 20mM
Tris-HCl (pH 8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSEYSNCGE NEYYNQTTGL CQECPPCGPG EEPYLSCGYG TKDEDYGCVP
CPAEKFSKGG YQICRRHKDC EGFFRATVLT PGDMENDAEC GPCLPGYYML ENRPRNIYGM VCYSCLLAPP
NTKECVGATS GASANFPGTS GSSTLSPFQH AHKELSGQGHLATALIIAMS TIFIMAIAIV LIIMFYILKT KPSAPACCTS HPGKSVEAQV
SKDEEKKEAP DNVVMFSEKD EFEKLTATPA KPTKSENDAS SENEQLLSRS VDSDEEPAPD KQGSPELCLL
SLVHLAREKS ATSNKSAGIQ SRRKKILDVY ANVCGVVEGL SPTELPFDCL EKTSRMLSSTYNSEKAVVKT WRHLAESFGL KRDEIGGMTD GMQLFDRIST AGYSIPELLT
KLVQIERLDA VESLCADILE WAGVVPPASQ PHAAS.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
