Catalogue number
PRO-557
Synonyms
C-reactive protein, CRP, PTX1, MGC88244, MGC149895.
Introduction
CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically ( up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.
Description
Human CRP produced in Human plasma having a molecular mass of 114 kDa.
It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease.
Source
Human Plasma.
Physical Appearance
Sterile Filtered clear solution.
Formulation
The protein solution is in 20mM TRIS buffer pH 8.0 containing 0.28M NaCl, 0.09% NaN3 and 5mM CaCl2.
Stability
Human CRP should be stored at 2-8°C. Do not freeze!
Purity
Greater than 96.0%.
References
Title: Elevation of Intact and Proteolytic Fragments of Acute Phase Proteins Constitutes the Earliest Systemic Antiviral Response in HIV-1 Infection
Publication: PLoS pathogens 6.5 (2010): e1000893.
Link: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000893#ppat-1000893-g006
Human Virus Test
Starting material donor has been tested and certified negative for antibodies to HIV-1,
HIV-2, HCV, HBSAG and HIV/HBV/HCV (PCR).
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
