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NKG2D

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NKG2D

商品详情参考文献相关资料

PURE - anti Human CD326 (EpCAM) -

Reference	Size	Price	Quantity	Add to cart
326PU-01MG	100 test	190,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

326PU-01MG

100 test

190,00 € tax excl.

Product Description

Isotype: IgG1
Tested Applications: FCM
Conjugated: PURE
Immunogen: Human small cell lung carcinoma cell line NCl-H69
Species Reactivity: Human
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO

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Large description:

The 1D11 monoclonal antibody reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.

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