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STAT3 (pS727) Antibody is a Rabbit Polyclonal antibody against STAT3 (pS727). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Target	STAT3 (pS727)
Reactivity	Human
Origin	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB
Recommended dilutions	WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S727 of human STAT3.
Purification	Affinity purified.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Calculated MW: 83 kDa/87 kDa/88 kDa Observed MW: 88 kDa
Swiss Prot	P40763
GeneID	6774
Gene Symbol	STAT3
Concentration	> 1 mg/ml
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.