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RUNX2 Antibody is a Rabbit Polyclonal antibody against RUNX2. This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Target	RUNX2
Reactivity	Human, Mouse
Origin	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB
Recommended dilutions	WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthetic peptide of human RUNX2.
Purification	Affinity purified.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Calculated MW: 54 kDa/55 kDa/56 kDa Observed MW: 70 kDa
Swiss Prot	Q13950
GeneID	860
Gene Symbol	RUNX2
Concentration	> 1 mg/ml
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.