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Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFR beta or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor alpha (PDGFR alpha) and PDGF receptor beta (PDGFR beta). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocations between chromosomes 5 and 12, that fuses this gene to that of the translocations, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Target	PDGFR beta
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human PDGFR beta expressed in E. Coli.
Isotype	IgG1
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	190 kDa
Swiss Prot	P09619
Buffer	Ascitic fluid containing 0.03% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.