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Complement C3 Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC against Complement C3. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Target	Complement C3
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Tested Applications	ELISA, WB
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant mouse Complement C3 protein (1321-1663 AA)
Purity	> 95%
Purification	Purified by Protein G chromatography.
Form	Liquid
Isotype	IgG
Conjugation	FITC
Storage	Aliquot and store at -20 °C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Swiss Prot	P01027
GeneID	12266
NCBI Accession	NP_033908.2 NM_009778.3
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.