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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. This antibody is supplied as crude ascites.

Target	PTPN11
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Tested Applications	WB
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Human PTPN11.
Purification	Mouse Monoclonal Antibody (Mab) supplied as crude ascites.
Isotype	IgG1κ
Conjugation	Unconjugated
Specificity	This PTPN11 monoclonal antibody is generated from mouse immunized with PTPN11 recombinant protein.
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot	Q06124
Buffer	Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.