NRG1 Antibody abx032738|产品详情|进口橙子视频旧款采购网

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NRG1 Antibody

品牌：

货号：abx032738

规格：80 μl

货期：

应用：

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NRG1 Antibody

商品详情参考文献相关资料

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

Target	NRG1
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	IHC
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Human NRG1.
Purification	Purified Rabbit Polyclonal Antibody.
Isotype	IgG
Conjugation	Unconjugated
Specificity	This NRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-229 amino acids from the Central region of human NRG1.
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot	Q02297
NCBI Accession	NP_001153467.1 NP_001153471.1 NP_001153473.1 NP_001153477.1 NP_001153480.1 NP_039250.2 NP_039251.2 NP_039252.2 NP_039253.1 NP_039254.1 NP_039256.2 NP_039258.1
Buffer	PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.