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Reacts with an antigen (FcγRI) constitutively expressed on monocytes, macrophages and blood dendritic cells. The antigen expression can be induced on neutrophils and eosinophils by interferon γ and granulocyte colony-stimulation factor. Human CD64 is a high affinity receptor for monomeric human IgG1 and IgG3 which is expressed on macrophages, monocytes, and gamma interferon induced neutrophils. CD64 plays an important role in clearance of immune complexes and in antibody dependent cytoxicity.

Target	CD62P
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Tissue/ cell preparation. Human platelets.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG1
Conjugation	APC
Specificity	This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
Storage	Store in the dark at 2-8 °C.
Molecular Weight	140kDa
Swiss Prot	P16109
GeneID	6403
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 3-5 working days.
Note	This product is for research use only.