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CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.

Target	CD117
Reactivity	Human, Monkey, Cow
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	MOLM-1 megakaryocytic cell line.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG1
Conjugation	PE
Specificity	Although CD117 is primarily a marker for non-lymphoid progenitor, it has been reported to be detected on early lymphoid progenitor. CD117 expression has been found on a small subset of resting NK cells (CD56 bright), and about 30% of immature CD3–/CD4–/CD8– thymocytes. CD117 is also expressed on mast cells and detected on non-hematopoietic cells such as reproductive system, melanocytes and embryonic brain.
Storage	Store in the dark at 2-8 °C.
Molecular Weight	145 kDa
Swiss Prot	P10721
GeneID	3815
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 3-5 working days.
Note	This product is for research use only.