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CDKN2A (pS8) Antibody abx032203|产品详情|进口橙子视频旧款采购网




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    CDKN2A (pS8) Antibody
    品牌:
    货号:abx032203
    规格:80 μl
    货期:

    CDKN2A (pS8) Antibody

    商品详情 参考文献 相关资料
    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

    Target CDKN2A (pS8)
    Reactivity Human
    Host Rabbit
    Clonality Polyclonal
    Tested Applications DB
    Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
    Immunogen Human CDKN2A (phospho-Ser8).
    Purification Peptide Affinity Purified Rabbit Polyclonal Antibody.
    Isotype IgG
    Conjugation Unconjugated
    Specificity This CDKN2A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S8 of human CDKN2A.
    Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
    Swiss Prot P42771
    Buffer PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
    Availability Shipped within 5-10 working days.
    Note This product is for research use only.
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