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NNT-1/BCSF-3 is a neurotrophic factor with B-cell-stimulating capabilities.  Expressed in the lymph nodes and spleen, NNT-1/BCSF-3 activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b) by binding and inducing the tyrosine phosphorylation of these receptors.  In vitro, it supports the survival of chick embryo motor and sympathetic neurons.  In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss, and B-cell hyperplasia associated with increases in serum IgG and IgM.  Recombinant Human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.

Source: E.coli

Synonyms: Novel Neurtrophin-1/B-Cell-Stimulating Factor-3, Cardiotrophin-like cytokine, Cardiotrophin-like cytokine factor 1 (CLCF1)

AA Sequence: MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.