PC4 and SFRS1 Interacting Protein 1 (PSIP1) is a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. PSIP1 is also involved particularly in lens epithelial cell gene regulation and stress responses. PSIP1 has a significant role in lens epithelial to fiber cell terminal differentiation. In addition, PSIP1 plays a protective role during stress-induced apoptosis. Furthermore, PSIP1 is a cellular cofactor for lentiviral integration.
Recombinant Human PSIP1 produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 61,546 Dalton. PSIP1 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
