GSK3B is a serine-threonine kinase that belongs to the glycogen synthase kinase subfamily. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in the GSK3B gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of the GSK3B gene may be significant to the pathogenesis of Alzheimer disease.
Description: GSK3B produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 426 amino acids (1-420a.a.) and having a molecular mass of 47.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).
GSK3B is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Physical Appearance: Sterile Filtered colorless solution.
Formulation: GSK3B protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH7.4), 0.5mM PMSF and 30% glycerol.
Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HAS or BSA).
Avoid multiple freeze-thaw cycles.