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Rapamycin IRA-3884-PI|产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
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    Rapamycin
    品牌：Peptides International
    货号：IRA-3884-PI
    规格：100mg
    货期：

    Rapamycin
    商品详情 参考文献 相关资料
    • Product Code: IRA-3884-PI
    • Synonyms/Product Alternate Names: Sirolimus; AY-22989; WY-090217; NSC-226080; Rapamune
    • mTOR Inhibitor

    • Rapamycin is a clinically useful immunosuppressant that inhibits the response to interleukin-2 blocking activation of T- and B-cells and induces autophagy. Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that binds to mTOR Complex1 (mTORC1), inhibiting the mammalian target of rapamycin (mTOR). It can also bind to mTORC2, leading to decreased glucose tolerance and insensitivity to insulin.

      • Stable for 2 years as supplied.
      • Protect from exposure to moisture.
      • Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

    • Storage Conditions: -20 °C
    • Purity: 98% NMR (Conforms)
    • Molecular Weight: 914.17
    • Molecular Formula: C51H79NO13
    • CAS Number: 53123-88-9

    • Kay, et al., Immunology, 72, 544 (1991).

    • Mita, et al., Cancer Biol. Ther., 2(4 Suppl 1), S169 (2003).

    • Lamming, et al., Science, 335, 1638 ( 2012).

    • Sarkar, et al., Cell Death and Differentiation, 16, 46 (2009).

    • A Flemming, et al., Nat. Chem. Biol., 11, 7 (2011).

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