Tumor Protein P53 Regulated Apoptosis Inducing Protein 1 (TP53AIP1) is expressed mainly in the thymus, and is localized to the mitochondrion. p53 induces TP53AIP1 production which then mediates p53- dependent apoptosis. Alternatively spliced transcript variants encoding diverse isoforms are known for TP53AIP1.TP53AIP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (1-124) and having a molecular mass of 15kDa.
TP53AIP1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
The TP53AIP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.