The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu. Human CXCL4 although stable at 25C 1 week, should be stored desiccated below -18C. Please prevent freeze-thaw cycles.
Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues. The CXCL4 protein was lyophilized in PBS buffer pH-7.4.
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
