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Ryanodine receptor 2 (RYR2) (pSer2030) pAb

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Ryanodine receptor 2 (RYR2) (pSer2030) pAb

品牌：Badrilla

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Ryanodine receptor 2 (RYR2) (pSer2030) pAb

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Ryanodine receptor 2 (RYR2) (pSer2030) pAb

$599.00

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Product code: A010-32
Unit Size: 50 µl

A fully validated, highly specific rabbit polyclonal anti-serum to Serine-2030 phosphorylated Ryanodine Receptor

The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. PKA, and not CaMKII, was able to phosphorylate Ser-2030 of RYR2 in vitro and in isolated cardiac myocyte cells.

Tested applications: Western blot (1:5000 dilution). Species recognition: human, rat, mouse, rabbit, canine and sheep.

Description	Lyophilised Rabbit polyclonal anti-serum containing IgG antibody specific for Ser-2030 (PKA) phosphorylated RYR2.
Immunogen	Synthetic peptide (TIRGRLLS(PO3H2)LVE2033) corresponding to amino acids surrounding the phosphorylated serine residue at position 2030 of RYR2 (human), conjugated to KLH.
Isotype	IgG
Purification	Raw serum
Species reactivity	The antibody recognises RYR2 phosphorylated at serine 2030 and binding is blocked in the presence of a peptide containing the phospho-Ser2030 epitope.
Tested applications	WB
Recommended dilution	WB 1:1000
Optimization	Optimal dilutions to be determined by end user
Storage	Lyophilised antibody is stable at 4 °C when stored with desiccant. Reconstitute lyophilised powder in 50 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles.
Storage	Lyophilised: 4 °C. Reconstituted:-80 °C
Datasheet	A010-32
MSDS	A010-32
Regulatory statement	Product for research use only. Not intended for diagnostic or therapeutic use.