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Sirt1 inhibitor.Potent inhibitor of yeast NAD-dependent histone deacetylase Sir2p (IC= 60 M). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

Additional Information

Synonyms	1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Product #	S-2441
CAS #	5690-03-9
Chemical Name	1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Formula	C13H10O2
MW	198.2
Appearance	White to off-white Solid
Purity	98%
Solubility	DMSO (100 mg/ml)
Storage Temp	+4°C
Therapeutic Area	Oncological Disorders
Use	Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells1,2 and sirtuins in human breast cancer cells

Additional Information

MDL Number	MFCD08705254
ChemACX	X1430392-1
InChI	InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
SMILES	c1ccc2c(c1)ccc3c2CCC(=O)O3