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Curvularin, Potent antibiotic

品牌：AG Scientific

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规格：1 mg

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CAS:10140-70-2Formula:C16H20O5MW:292.3Appearance:WhitesolidPurity:>99%byHPLC

商品详情参考文献相关资料

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.

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Additional Information

Synonyms	S-Curvularin, NSC 166071
Product #	C-2675
CAS #	10140-70-2
Formula	C16H20O5
MW	292.3
Appearance	White solid
Purity	>99% by HPLC
Solubility	Soluble in methanol, dioxane, pyridine
Storage Temp	-20°C
Use	A potent antifungal and mycotoxin that also inhibits NO production

Additional Information

MDL Number	MFCD09752718
InChI	InChI=1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1
SMILES	C[C@H]1CCCCCC(=O)c2c(cc(cc2O)O)CC(=O)O1

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