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Tozasertib

品牌：AG Scientific

货号：

规格：25 mg

货期：

应用：

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CAS:639089-54-6Formula:C23H28N8OSMW:464.59Appearance:Whitetooff-whiteSolidPurity:99%byHPLC

商品详情参考文献相关资料

Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.

Additional Information

Synonyms	MK-0457, VX6, VX-681
Product #	T-2466
CAS #	639089-54-6
Chemical Name	N-(4-(4-(3-METHYL-1H-PYRAZOL-5-YLAMINO)-6-(4-METHYLPIPERAZIN-1-YL)PYRIMIDIN-2-YLTHIO)PHENYL)CYCLOPROPANECARBOXAMIDE
Formula	C₂₃H₂₈N₈OS
MW	464.59
Appearance	White to off-white Solid
Purity	99% by HPLC
Solubility	DMSO (100 mg/ml)
Melting Point	245-260 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Tozasertib is a potent pan-ARK inhibitor but favors ARK-1.Tozasertib effectively inhibits proliferation of renal carcinoma

Additional Information

MDL Number	MFCD13185152
ChemACX	X1653617-5
InChI	InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
SMILES	Cc1cc(n[nH]1)Nc2cc(nc(n2)Sc3ccc(cc3)NC(=O)C4CC4)N5CCN(CC5)C

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