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A glycylglycine type of antibiotic derived from tetracycline. Inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains.

Additional Information

Synonyms	N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5,5a,6,6a,7,8,9,10,10a,11-decahydrotetracen-2-yl]-2-(tert-butylamino)acetamide
Product #	T-2461
CAS #	220620-09-7
Chemical Name	N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5,5a,6,6a,7,8,9,10,10a,11-decahydrotetracen-2-yl]-2-(tert-butylamino)acetamide
Formula	C29H39N5O8
MW	586.65
Appearance	Off-white to yellow brown Solid
Purity	98% by HPLC
Solubility	DMSO (~ 3 mg/ml with warming)
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Tigecycline is an antibiotic, have activity against a variety of Gram-positive and Gram-negative bacterial infection

Additional Information

MDL Number	MFCD00935753
ChemACX	X1608630-3
InChI	InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1
SMILES	CC(C)(C)NCC(=O)NC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=C(C(=O)[C@]4(C(=C3C(=O)C2=C1O)O)O)C(=O)N)O)N(C)C)N(C)C