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SU 1498

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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Formula:C25H30N2O2MW:390.52Appearance:YellowPowderPurity:98%byTLC

商品详情参考文献相关资料

A potent and selective inhibitor (IC= 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 M), EGFR-kinase (IC100 M)and HER-2 kinase (IC100 M). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.

Additional Information

Synonyms	Tyrphostin SU 1498; (E)-N-(3-Phenylpropyl)-cyano-3,5-diisopropyl-4-hydroxycinnamamide
Product #	S-2447
Chemical Name	Tyrphostin SU 1498; (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
Formula	C₂₅H₃₀N₂O₂
MW	390.52
Appearance	Yellow Powder
Purity	98% by TLC
Solubility	DMSO (~20 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 in tumor growth.

Additional Information

MDL Number	MFCD03453026
ChemACX	X1276572-1
InChI	InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
SMILES	CC(C)c1cc(cc(c1O)C(C)C)/C=C(C#N)/C(=O)NCCCc2ccccc2

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