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Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntingtons Disease (HD).

Additional Information

Synonyms	Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
Product #	S-2436
CAS #	307538-42-7
Chemical Name	Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
Formula	C11H10BrN3
MW	264.12
Appearance	Off-White Solid
Purity	98% by TLC
Solubility	DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	SMER28 is a small molecule modulator of mammalian autophagy for the treatment of Alzheimer's disease & Huntingtons Disease (HD)

Additional Information

MDL Number	MFCD02166825
ChemACX	X1621469-2
InChI	InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
SMILES	C=CCNc1c2cc(ccc2ncn1)Br