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Selective telomerase inhibigtor (ICvalues are 93, 100000 and 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCl-H460 lung carcinoma cells and eventual growth arrest.

Additional Information

Synonyms	2-[[(2E)-3(2-Naphtalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Product #	B-2377
CAS #	321674-73-1
Chemical Name	2-[[(2E)-3(2-Naphtalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Formula	C21 H17 N O3
MW	331.36
Appearance	Solid
Purity	98%
Solubility	Soluble to 100nM in DMSO and to 25 mM in ethanol
Storage Temp	Room Temp
Therapeutic Area	Oncological Disorders
Use	Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells

Additional Information

MDL Number	MFCD11112195
ChemACX	X1763947-3
InChI	InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
SMILES	C/C(=CC(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2