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AEBSF HCl

品牌：AG Scientific

货号：

规格：50 mg

货期：

应用：

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CAS:30827-99-7Formula:C8H10FNO2S.HClMW:239.69Appearance:Whitetooff-whitepowderPurity:≥98%

商品详情参考文献相关资料

AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural.

AEBSF also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits Dipeptidyl peptidase IV (DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.

Additional Information

Synonyms	Pefabloc SC; 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Product #	A-1018
CAS #	30827-99-7
Chemical Name	4-(2-Aminoethyl)-bezenesulfonylfluoride.HCl
Formula	C₈H₁₀FNO₂S.HCl
MW	239.69
Appearance	White to off-white powder
Purity	≥98%
Solubility	Clear colorless solution at 50mg/ml in H2O
Melting Point	182-184 °C
Storage Temp	Store desiccated at -20°C
Use	AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor

Additional Information

MDL Number	MFCD00132962
ChemACX	X1086833-8
InChI	InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
SMILES	c1cc(ccc1CCN)S(=O)(=O)F.Cl

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