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Rocaglamide

品牌：AG Scientific

货号：

规格：100 ug

货期：

应用：

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CAS:84573-16-0Formula:C29H31NO7MW:505.56Appearance:Whitetooff-whiteSolidPurity:98%byHPLC

商品详情参考文献相关资料

An immunosuppressant and a potent inhibitor of NF-B activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-, TNF, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-B and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.

Additional Information

Synonyms	Rocaglamide A
Product #	R-2420
CAS #	84573-16-0
Chemical Name	(1R,2R,3S,3AR,8BS)-1,8B-DIHYDROXY-6,8-DIMETHOXY-3A-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-PHENYL-2,3-DIHYDRO-1H-CYCLOPENTA[B][1]BENZOFURAN-2-CARBOXAMIDE
Formula	C₂₉H₃₁NO₇
MW	505.56
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	Soluble in DMSO or EtOH
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Rocaglamide is a potent anticancer agent

Additional Information

MDL Number	MFCD08702699
ChemACX	X1881329-5
InChI	InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
SMILES	CN(C)C(=O)[C@@H]1[C@H]([C@]2([C@@]([C@@H]1O)(c3c(cc(cc3OC)OC)O2)O)c4ccc(cc4)OC)c5ccccc5

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