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A23187, Free Acid

品牌：AG Scientific

货号：

规格：5 mg

货期：

应用：

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CAS:52665-69-7Formula:C29H37N3O6MW:523.6Appearance:WhitePowderPurity:98%

商品详情参考文献相关资料

A23187 is a carboxylic acid antibiotic derived from cultures of Streptomyces chartreusensis that transports divalent cations across cell membranes, which are usually impermeable to them. This mobiles Ion - carrier forms stable complexes with divalent cations (ions with a charge of +2). The ionophore is used in laboratories to increase intracellular Ca²⁺ levels in intact cells. A23187 has antibiotic properties against gram-positive Bacteria and fungi. A23187 also induces apoptosis in some cells (e.g. mouse lymphoma cell line, or S49, and Jurkat cells). Recent clinical studies indicate that treatment of oocytes lacking a 2ndPb with A23187 at 4.5–5.0 h after ICSI (Intracytoplasmic sperm injection) is expected to be effective at preventing fertilization failure.

Additional Information

Synonyms	Calcium Ionophore A23187, Calcimycin, Antibiotic A23187, Calcium Ionophore
Product #	A-1020
CAS #	52665-69-7
Chemical Name	5-(METHYLAMINO)-2-[(2R,3R,6S,8S,9R,11R)-3,9,11-TRIMETHYL-8-[(1S)-1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)-ETHYL]-1,7-[DIOXASPIRO[5.5]UNDEC-2-YL]METHYL]-4-BENZOXAZOLECARBOXYLIC ACID
Formula	C₂₉H₃₇N₃O₆
MW	523.6
Appearance	White Powder
Purity	98%
Solubility	Soluble in Methanol and Acetic Acid
Melting Point	190°C
Storage Temp	Store at -20°C
Therapeutic Area	Infectious Diseases
Use	A23187 has antibiotic properties against gram positive bacteria and fungi

Additional Information

MDL Number	MFCD00151202
ChemACX	X1001942-8
InChI	InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
SMILES	C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)c3ccc[nH]3)C)C)O[C@H]1Cc4nc5c(o4)ccc(c5C(=O)O)NC

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