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*Please inquire the availability for this product. UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.

Additional Information

Synonyms	7-Hydroxystaurosporine
Product #	U-2575
CAS #	112953-11-4
Chemical Name	(2S,3R,4R,6R,18R)-18-HYDROXY-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]NONACOSA-8,10,12,14,19,21,23,25,27-NONAEN-16-ONE
Formula	C28H26N4O4
MW	482.5
Appearance	White Film
Purity	>99% by HPLC
Therapeutic Area	Oncological Disorders
Use	UCN-01 (7-Hydroxystaurosporine) is an anticancer agent

Additional Information

MDL Number	MFCD01782559
InChI	InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
SMILES	C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)N[C@@H]8O)NC)OC