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Thiosestrepton CAS 1393-48-2 ointment for companion animals, Thiosestrepton CAS 139

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Thiosestrepton CAS 1393-48-2 ointment for companion animals, Thiosestrepton CAS 139

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CAS:1393-48-2Formula:C72H85O18N19S5MW:1664.89Appearance:WhitetoLightYellowPowder

商品详情参考文献相关资料

Thiosestreptin is a thiazole-containing peptide antibiotic used in molecular biology applications. The thiosestrepton-resistant gene is commonly used as a selective marker for recombinant DNA/plasmid technologies. Thiosestrepton inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. Activation of TLR7–9 has been linked to autoimmune diseases such as rheumatoid arthritis, lupus, and psoriasis. Thiosestrepton has been shown to be a novel TLR7–9 inhibitor¹. Thiosestrepton inhbits FoxM1 which ultimately suppresses tumor formation in ovarian cancer cells².

1.) http://www.jimmunol.org/content/195/8/3912.abstract?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitle=and&titleabstract=thiosestrepton&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&tdate=4/30/2016&resourcetype=HWCIT

2.) http://carcin.oxfordjournals.org/content/36/4/498.full.pdf+html

Additional Information

Synonyms	Thio, Alaninamide; Bryamycin; Thiactin; EINECS 215-734-9
Product #	T-1202
CAS #	1393-48-2
Chemical Name	N-(3-[(3-AMINO-3-OXO-1-PROPEN-2-YL)AMINO]-3-OXO-1-PROPEN-2-YL)-2-[(1R,8S,11Z,15S,18S,25S,26R,35R,37S,40S,46S,53S,59S)-37-[(2S)-2-BUTANYL]-18-[(2S,3R)-2,3-DIHYDROXY-2-BUTANYL]-11-ETHYLIDENE-59-HYDROXY- 8-[(1R)-1-HYDROXYETHYL]-31-[(1S)-1-HYDROXYETHYL]-26,40
Formula	C₇₂H₈₅O₁₈N₁₉S₅
MW	1664.89
Appearance	White to Light Yellow Powder
Solubility	Soluble in DMSO, chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water.
Melting Point	246-256 °C
Storage Temp	-20°C for long term storage.
Therapeutic Area	Infectious Diseases
Use	A protein synthesis-inhibiting antibiotic active against gram-positive bacteria

Additional Information

MDL Number	MFCD00135828
ChemACX	X1011724-3
InChI	InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-/t26-,30-,31-,32-,33+,34+,35+,39+,45+,47-,48-,49-,51-,52+,53+,71+,72+/m0/s1
SMILES	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)NC(=C)C(=O)N[C@H](C(=O)N[C@]23CCC(=N[C@@H]2c4csc(n4)[C@H]([C@H](OC(=O)c5cc(c6c(n5)[C@H]([C@H](N1)C=C6)O)[C@H](C)O)C)NC(=O)c7csc(n7)[C@@H](NC(=O)[C@H]8CSC(=N8)/C(=C/C)/NC(=O)[C@@H](NC(=O)c9csc3n9)[C@@H](C)O)[C@@](C)([C@@H](

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