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17DMAG

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:467214-20-6Formula:C32H48N4O8MW:616.8Appearance:PurplePowderPurity:98%byTLC

商品详情参考文献相关资料

17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin (G-1047) and 17-AAG (A-1256), 17-DMAG binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation. HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosesensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosesensitivity of human cancer cells.

Additional Information

Synonyms	NSC 707545
Product #	A-1298
CAS #	467214-20-6
Chemical Name	17-[2- (Dimethylamino)ethyl]amino-17- desmethoxygeldanamycin
Formula	C₃₂H₄₈N₄O₈
MW	616.8
Appearance	Purple Powder
Purity	98% by TLC
Solubility	Soluble in DMSO, Methanol, Ethanol
Preparation	Clear purple solution at 10mg 17DMAG in 1ml of Methanol, or 25mg 17DMAG in 1ml DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	17-DMAG is used to inhibit cancer growth and to promote apoptosis in multiple cell lines

Additional Information

MDL Number	MFCD08457919
ChemACX	X1578552-3
InChI	InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1
SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)C)C)O)OC

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