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An aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Also has high binding affinity to phosphatidylinositol 4,5-bisphosphate (PIP₂).

We have demonstrated that neomycin was effective as secondary prophylaxis for irinotecan-induced diarrhea in three patients, and may have contributed to the prevention of diarrhea in a further two patients.¹Neomycin as secondary prophylaxis for irinotecan-induced diarrhea, A. Schmittel, K. Jahnke, E., et al, Aug 2004; 15: 1296.

Neomycin Restores the Insulin-stimulated Glucose Transport Inhibited by the PI3K Inhibitor Wortmannin.²Neomycin Prevents the Wortmannin Inhibition of Insulin-stimulated Glut4 Translocations and Glucose Transport in 3T3-L1 Adipocytes, Declan J. James, Christine Salaün, et al, May 2004; 279: 20567 - 20570.

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