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KU-55933

品牌：AG Scientific

货号：

规格：5 mg

货期：

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CAS:587871-26-9Formula:C21H17NO3S2MW:395.49Appearance:WhiteSolidPurity:97%byHPLC

商品详情参考文献相关资料

A potent, selective and ATP-competitive inhibitor of ATM Kinase (K = 2.2 nM; IC= 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC= 2500, 9300, 16600, 100000 and 100000 nM, respectively). KU-55933 inhibits cancer cell proliferation by inducing G(1) cell-cycle arrest. Sensitizes cells to ionizing radiations and chemotherapeutics. Induces apoptosis in breast and prostate cancer cell lines.

Additional Information

Synonyms	2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
Product #	A-2189
CAS #	587871-26-9
Chemical Name	2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
Formula	C₂₁H₁₇NO₃S₂
MW	395.49
Appearance	White Solid
Purity	97% by HPLC
Solubility	DMSO (100 mM) and Ethanol (50 mM)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A cell-permeable, potent, selective and ATP-competitive ATM inhibitor use in cancer

Additional Information

MDL Number	MFCD08276985
ChemACX	X1544046-5
InChI	InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
SMILES	c1ccc2c(c1)Sc3cccc(c3S2)c4cc(=O)cc(o4)N5CCOCC5

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