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JIB-04

品牌：AG Scientific

货号：

规格：5 mg

货期：

应用：

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CAS:199596-05-9Formula:C170H13CIN4MW:308.8Appearance:yellowpowderPurity:>98%(TLC);NMR(Conforms)

商品详情参考文献相关资料

A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC₅₀ = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.

A recent study has shown that JIB-04 increases the expression of PD-L1 in SUM149-MA breast cancer cell lines. Increased PD-L1 expression in breast cancer cell lines renders them responsive to various therapies not just immune checkpoint blockade of PD-L1. Hence these results suggest that JIB-04 is a potential anti-cancer agent that can halt cancer progression and prevent resistance to therapies.

Additional Information

Product #	J-2519
CAS #	199596-05-9
Chemical Name	(E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
Formula	C₁₇₀H₁₃CIN₄
MW	308.8
Appearance	yellow powder
Purity	>98% (TLC); NMR (Conforms)
Solubility	May be dissolved in DMSO (30 mg/ml)
Storage Temp	Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.