The resorcyclic acid lactone Hypothemycin isolated from Phoma sp. has antifuangal and anticancer activity.

Hypothemycin normalized the morphology and inhibited anchorage-independent growth of Ki-ras transformed normal rat kidney(NRK) cells with selectivity and potency comparable to or greater than that of the MEK inhibitor U0126. It is also potent and selective threonine/tyrosine-specific kinase.

Hypothemycin inhibits proliferation of mouse and human T-cells and modulates production of cytokines during T-cell activation. It facilitates the ubiquitinylation process of cyclin D1.

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Product References

• The Resorcylic Acid Lactone Hypothemycin Selectively Inhibits the Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway in Cells, Biol. Pharm, Hidesuke Fukazawa, 33(2) (2010)?

• Gene for the Biosesynthesis of the Fungal Polyketides Hypothemycin from Hypomyces subiculosus and Radicicol from Pochonia chlamydosporia, Microbiol, Christopher D. Reeves, et al., vol. 74, no. 16 (2008)

• Semiynthesis and Cytotoxicity of Hypothemycin Analogues, ChemMedChem, Brian R.Hearn Dr., et al., vol. 2 (2007)

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Additional Information

Additional Information