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UNC-2170

品牌：AG Scientific

货号：

规格：5 mg

货期：

应用：

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CAS:1648707-58-7Formula:C14H21BrN2O.HClMW:349.7Appearance:whitepowderPurity:>98%

商品详情参考文献相关资料

The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a micro M ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain1.

References:

1. MT Perfetti et al. ACS Chem. Biol. 2015 10:1072

Additional Information

Synonyms	3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
Product #	M-2753
CAS #	1648707-58-7
Formula	C₁₄H₂₁BrN₂O . HCl
MW	349.7
Appearance	white powder
Purity	>98%
Solubility	May be dissolved in DMSO or water
Melting Point	162-164°C
Storage Temp	-20°C