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Biologically active form of Vitamin D3 in intestinal calcium transport and bone |产品详情|进口橙子视频旧款采购网




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    Biologically active form of Vitamin D3 in intestinal calcium transport and bone
    品牌:AG Scientific
    货号:
    规格:100 ug
    货期:

    CAS:32222-06-3Formula:C27H44O3MW:416.64Appearance:ColorlesslyophilizedsolidPurity:>98%

    商品详情 参考文献 相关资料

    Calcitriol is the most active form of Vitamin D that exists as a small lipophilic molecule with superior cellular penetration. Calcitriol binds to intracellular vitamin D receptor (VDR) in most cells in the body by functioning both as a paracrine and an autocrine agent. Calcitriol plays an important role in mineral homeostasis and bone growth by promoting the export of calcium from bone, absorption of calcium from the gastrointestinal tract and the stimulation of the absorption of phosphate and magnesium ions to support mineralization. Calcitriol has potent effects on factors involved in growth and differentiation of many types of cancer cells, as well as cell adhesion and apoptosis. This could be largely due to its role in regulating the cell cycle and number of genes that are implicated in cancer initiation. Calcitriol has been shown to exhibit anti-proliferative, pro-differentiating, pro-apoptotic and anti-inflammatory actions in a variety of cancer cells in vitro including prostate cancer cells

    Calcitriol is used for preclinical studies and research. Many preclinical studies have demonstrated that  exposure to high calcitriol concentrations can result in inhibition of prostate cancer cell growth in vitro and retardation or slow-down tumor growth in animal models of prostate cancer. Recent studies have suggested that calcitriol-induced increased absorption of phosphate from the intestine might also be involved in the increase of fibroblast growth factor-23 (FGF23).

    *Inquire to confirm pacakge size, formulation, current price. Bulk also available.

    Additional Information

    Synonyms1-25-dihydroxyvitamin D3
    Product #C-1026
    CAS #32222-06-3
    Chemical Name1-α-25-dihydroxyvitamin D3
    FormulaC27H44O3
    MW416.64
    AppearanceColorless lyophilized solid
    Purity>98%
    SolubilityMay be dissolved in DMSO (25 mg/ml); or Ethanol (25 mg/ml)
    Melting Point111.1-115 °C
    Storage TempStore desiccated at -20°C. PROTECT FROM LIGHT!
    Therapeutic AreaNutritional Disorders
    UseCalcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood

    Additional Information

    MDL NumberMFCD00867079
    ChemACXX1000636-1
    InChIInChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/t18-,22-,23-,24+,25+,27-/m1/s1
    SMILESC[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CCCC2=CC=C3C[C@H](C[C@@H](C3=C)O)O)C
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