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*Please inquire the availability for this product. Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 α¼g/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. FASII is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding to Liver X receptors (LXR). These receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.

Additional Information

Synonyms	BABX
Product #	B-2553
CAS #	866022-28-8
Formula	C28H24O7Cl2
MW	542.1
Appearance	Light orange residue
Purity	>99% by HPLC
Solubility	Soluble in water (limited), ethanol, methanol, DMSO, and DMF
Storage Temp	-20°C
Use	A selective inhibitor of Type II fatty acid synthesis (FASII)

Additional Information

MDL Number	MFCD14635432
InChI	InChI=1S/C28H24Cl2O7/c1-10-6-12(35-5)8-14-15(10)26-16-11(9-28(4,36-14)37-26)7-13-17(22(16)31)23(32)18-19(27(13,2)3)20(29)25(34)21(30)24(18)33/h6-8,26,31,33-34H,9H2,1-5H3
SMILES	C1(=C(C(=C(C6=C1C(C5=CC3=C(C4C2=C(C=C(C=C2OC(C3)(O4)C)OC)C)C(=C5C6=O)O[H])(C )C)O[H])Cl)O[H])Cl