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AG 879

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:148741-30-4Formula:C18H24N2OSMW:316.5Appearance:Off-whitetoyellowsolidPurity:≥98%

商品详情参考文献相关资料

AG 879 or Tyrphostin AG 879 inhibits the tyrosine kinase activity of nerve growth factor(NGF)-dependent TrKA tyrosine phosphorylation in in PC-12 cells (IC₅₀ = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC₅₀ = ~0.5 μM). It acts as an antiproliferative agent for diseases caused by the hyperactivity of PTKs. AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC₅₀ = 15 μM) in schwannoma cells.

Additional Information

Synonyms	Tyrphostin AG 879
Product #	A-1198
CAS #	148741-30-4
Chemical Name	(3,5-Di-t-butyl-4-hydroxybenzylidene)thiocyanoacetamide alpha-Cyano-(3,5-di-tert.butyl-4-hydroxy)thiocinnamamide
Formula	C₁₈H₂₄N₂OS
MW	316.5
Appearance	Off-white to yellow solid
Purity	≥98%
Solubility	Soluble in DMSO and Ethanol.
Storage Temp	-20°C