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Nilotinib

品牌：AG Scientific

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CAS:641571-10-0Formula:C28H22F3N7OMW:529.52Appearance:Off-WhiteSolidPurity:98%byHPLC

商品详情参考文献相关资料

A potent, selective BCR-ABL inhibitor that fits into the ATP- of the BCR-ABL protein with higher affinity than imatinib (Cat. No. 1625-100, 1000). Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC< 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants.

Additional Information

Product #	N-2364
CAS #	641571-10-0
Formula	C₂₈H₂₂F₃N₇O
MW	529.52
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	Soluble in DMSO (50 mg/ml)
Melting Point	230-242 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Nilotinib is rationally designed c-Abl and Bcr-Abl kinase inhibitor used to treat certain types of chronic myeloid leukemia

Additional Information

MDL Number	MFCD09833716
ChemACX	X1616869-9
InChI	InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
SMILES	Cc1ccc(cc1Nc2nccc(n2)c3cccnc3)C(=O)Nc4cc(cc(c4)n5cc(nc5)C)C(F)(F)F

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